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The Clinical Course of Neuromyelitis Optica (Devic's Syndrome) Neurol 53:1107-1114, Wingerchuk,D.M.,et al, 1999 See this aricle in Pubmed Article Abstract Most relapsing patients developed severe disability in a stepwise manner, and one-third died because of respiratory failure. Features of NMO distinct from "typical" MS included >50 cells/mm in CSF (often polymorphonuclear), normal initial b rain MRI, and lesions extending over three or more vertebral segments on spinal cord MRI. Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS. Patients with relapsing optic neuritis and myelitis may have neuromyel itis optica rather than MS. Patients with a relapsing course of neuromyelitis optica have a poor prognosis and frequently develop respiratory failure during attacks of cervical myelitis.

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